Polystyrene nanoplastics exposure induces cognitive impairment in mice via induction of oxidative stress and ERK/MAPK-mediated neuronal cuproptosis
This study presents preliminary evidence indicating that PS-NPs may induce neuronal cuproptosis, potentially through the oxidative stress-mediated activation of the ERK-MAPK pathway, which contributes to cognitive dysfunction in mice. These findings provide insights into the potential mechanisms underlying PS-NPs neurotoxicity and highlight possible therapeutic targets, such as copper chelation or MAPK inhibition, for mitigating the neurological risks associated with nanoplastic exposure, pending further validation in human-relevant models.
Authors
- Yinuo Chen (ORCID: https://orcid.org/0000-0003-2130-5965)
- Yan Zeng (ORCID: https://orcid.org/0000-0002-5119-5448)
- Nan Yu (ORCID: https://orcid.org/0000-0002-0177-2067)
- Jinquan Li (ORCID: https://orcid.org/0000-0003-0498-5399)
- Lang Xu
- Anqi Dai
- Rosa Maria Martinez Orteg
- Mantong Ma
Institutions
- University of the Gambia (GM)
- Edward Francis Small Teaching Hospital (GM)
- Wuhan University (CN)
- Wuhan University of Science and Technology (CN)
Publication Details
- Journal
- Particle and Fibre Toxicology
- Published
- 2025-05-20
- DOI
- https://doi.org/10.1186/s12989-025-00633-w
- Citations
- 44
- Primary Topic
- Microplastics and Plastic Pollution
- Type
- article
- Field-Weighted Citation Impact
- 22.16
Funders
- Hubei Provincial Department of Education
- Natural Science Foundation of Hubei Province
- Wuhan University
- Wuhan University of Science and Technology