VPS37A Activates the Autophagy-Lysosomal Pathway for TNFR1 Degradation and Induces NF-<b>κ</b>B-Regulated Cell Death under Metabolic Stress in Colorectal Cancer
VPS37A deficiency drives CRC progression by sustaining TNFR1/NF-κB signaling under metabolic stress. Restoring VPS37A activity promotes TNFR1 degradation, offering a therapeutic strategy to counteract NF-κB-mediated treatment resistance in CRC.
Authors
- Bangdong Liu (ORCID: https://orcid.org/0000-0002-9460-3739)
- Ran Zhao (ORCID: https://orcid.org/0000-0002-1004-490X)
- Yushan Wei (ORCID: https://orcid.org/0000-0002-4684-6074)
- Ziqi Li (ORCID: https://orcid.org/0000-0002-6345-4347)
- Xiaohan Liu (ORCID: https://orcid.org/0000-0002-1154-8122)
- Yukun Liu (ORCID: https://orcid.org/0000-0002-6035-7920)
- Chuncheng Liu (ORCID: https://orcid.org/0000-0001-5451-5550)
Institutions
- Shandong University (CN)
- Affiliated Hospital of Jining Medical University (CN)
Publication Details
- Journal
- Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics
- Published
- 2025-01-01
- DOI
- https://doi.org/10.32604/or.2025.065739
- Citations
- 2
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 2.71