Spatiotemporal T-cell tracking for personalized T-cell receptor T-cell therapy designs in childhood cancer
These findings strongly support spatiotemporal tracking of T-cell activity in response to ICI to inform therapy efficacy and to serve as a source of tumor-reactive TCRs for personalized TCR-T designs.
Authors
- Michael Grzelak (ORCID: https://orcid.org/0000-0003-4812-8137)
- C. Sauvage
- Quirze Rovira (ORCID: https://orcid.org/0000-0002-1472-1250)
- Inés Sentís (ORCID: https://orcid.org/0000-0001-8320-9579)
- Ginevra Caratù (ORCID: https://orcid.org/0000-0003-1085-8062)
- Juan C. Nieto (ORCID: https://orcid.org/0000-0002-3400-1488)
- Alexandre Harari (ORCID: https://orcid.org/0000-0002-1055-2090)
- Davide Maspero
- Cinzia Lavarino (ORCID: https://orcid.org/0000-0002-9630-3676)
- Andrea Urpi (ORCID: https://orcid.org/0000-0002-2437-7094)
- Carlos J. Rodríguez-Hernández (ORCID: https://orcid.org/0000-0002-5867-3182)
- Holger Heyn (ORCID: https://orcid.org/0000-0002-3276-1889)
- Anna Pascual Reguant (ORCID: https://orcid.org/0000-0002-5042-3699)
- Alexandra Avgustinova (ORCID: https://orcid.org/0000-0001-6016-2931)
- Juan L. Melero (ORCID: https://orcid.org/0000-0003-1387-6231)
- Ana Mendizabal-Sasieta
- Marta Soto (ORCID: https://orcid.org/0000-0002-9949-1908)
- Aude Michel (ORCID: https://orcid.org/0009-0007-1111-5910)
- J. Mora
- A. Castañeda Heredia
- Alex Cebria‐Xart (ORCID: https://orcid.org/0009-0003-4552-190X)
- Juan Pablo Muñoz Perez
Institutions
- Hospital Sant Joan de Déu Barcelona (ES)
- Sant Joan de Déu Research Foundation (ES)
- Centro Nacional de Análisis Genómico (ES)
- Institut de Recerca Sant Joan de Déu
Publication Details
- Journal
- Annals of Oncology
- Published
- 2025-05-20
- DOI
- https://doi.org/10.1016/j.annonc.2025.05.530
- Citations
- 1
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- Institute for Research in Biomedicine
- Centres de Recerca de Catalunya
- European Commission
- Generalitat de Catalunya
- Ministerio de Economía y Competitividad
- Agencia Estatal de Investigación