Novel Perivascular Macrophage Mechanism to Promote Glymphatic Aβ Clearance After Stroke
In summary, supplementation of MANF not only mitigates the adverse impacts of PBM depletion but also exerts therapeutic effects that improve glymphatic system function. We thus propose that this represents a promising strategy to prevent poststroke cognitive impairment.
Authors
- Tracy D. Farr (ORCID: https://orcid.org/0000-0002-6781-5226)
- Danli Lu
- Xiaohui Deng (ORCID: https://orcid.org/0000-0002-4339-237X)
- Mengyan Hu (ORCID: https://orcid.org/0000-0002-3501-028X)
- Huipeng Huang
- Xiaotao Su (ORCID: https://orcid.org/0000-0003-3710-1975)
- Shishi Shen
- Zhengqi Lu (ORCID: https://orcid.org/0000-0002-2118-0368)
- Tiemei Li (ORCID: https://orcid.org/0000-0002-5727-2280)
- Wei Cai (ORCID: https://orcid.org/0000-0003-4059-4627)
- Shisi Wang (ORCID: https://orcid.org/0000-0002-6484-7169)
- Yuxin Liu
- Xinmei Kang (ORCID: https://orcid.org/0000-0002-3039-5221)
- Chunyi Li (ORCID: https://orcid.org/0000-0001-5843-9882)
Institutions
- University of Nottingham (GB)
- Sun Yat-sen University (CN)
- Key Laboratory of Guangdong Province (CN)
- Fifth Affiliated Hospital of Sun Yat-sen University (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
- Guangdong 999 Brain Hospital (CN)
Publication Details
- Journal
- Stroke
- Published
- 2025-05-20
- DOI
- https://doi.org/10.1161/strokeaha.124.050266
- Citations
- 5
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 4.55