STAR Locally Prolongs Effective Refractory Period and Increases Ventricular Tachycardia Cycle Length Without Short-Term Scar Formation or Functional Decline: Insights From a Translational Porcine Model Study

Our data suggest a novel therapeutic mechanism of STAR driven by increasing the effective refractory period in locally treated areas, corresponding to increased tissue wavelength. Our results corroborate clinical case reports and anecdotal evidence that STAR increases VT cycle length. Importantly, these effects were not mediated by an increase in myocardial scar burden. However, our studies do not examine the long-term effects of STAR.

Authors

Ali Javaheri (ORCID: https://orcid.org/0000-0001-6657-331X)
Samuel D. Jordan (ORCID: https://orcid.org/0009-0007-2692-8746)
Carmen Bergom (ORCID: https://orcid.org/0000-0002-0886-5055)
Aryan Kumar
El‐Sayed H. Ibrahim (ORCID: https://orcid.org/0000-0003-4292-4669)
Pamela Samson (ORCID: https://orcid.org/0000-0003-2448-2123)
Vinay P. Jani (ORCID: https://orcid.org/0000-0003-3092-1639)
Stacey Rentschler (ORCID: https://orcid.org/0000-0002-1744-1238)
Brian Zenger (ORCID: https://orcid.org/0000-0002-0039-9184)
Todd Pavek (ORCID: https://orcid.org/0009-0007-7460-9141)
Christian W. Zemlin (ORCID: https://orcid.org/0000-0001-5834-5544)
Luke Marut
Patrick M. Boyle (ORCID: https://orcid.org/0000-0001-9048-1239)
Sneha Manikandan
Jie Zheng (ORCID: https://orcid.org/0000-0002-2310-2996)
Sherwin Ng (ORCID: https://orcid.org/0000-0002-4797-1694)
Clifford G. Robinson (ORCID: https://orcid.org/0000-0002-1399-9904)
Phillip S. Cuculich (ORCID: https://orcid.org/0000-0001-8127-2240)
Geoffrey D. Hugo (ORCID: https://orcid.org/0000-0002-4109-8177)
Julie K. Schwarz (ORCID: https://orcid.org/0000-0003-2407-7531)
Stephanie N. Hicks (ORCID: https://orcid.org/0000-0002-0651-725X)
Timothy W. Smith (ORCID: https://orcid.org/0000-0002-7307-855X)
Leslie Dawn Wilson
Nels Knutson
Caleb Berberet
James Tabor

Institutions

California Institute for Regenerative Medicine (US)
Medical College of Wisconsin (US)
Washington University in St. Louis (US)
John Cochran VA Medical Center (US)
Norwegian Womens Public Health Association (NO)
Bioengineering Center (RU)

Publication Details

Journal: Circulation Arrhythmia and Electrophysiology
Published: 2025-05-20
DOI: https://doi.org/10.1161/circep.124.013684
Citations: 3
Primary Topic: Cardiac Arrhythmias and Treatments
Type: article
Field-Weighted Citation Impact: 4.16

STAR Locally Prolongs Effective Refractory Period and Increases Ventricular Tachycardia Cycle Length Without Short-Term Scar Formation or Functional Decline: Insights From a Translational Porcine Model Study

Ali Javaheri, Samuel D. Jordan, Carmen Bergom, Aryan Kumar, El‐Sayed H. Ibrahim, Pamela Samson, Vinay P. Jani, Stacey Rentschler, Brian Zenger, Todd Pavek, Christian W. Zemlin, Luke Marut, Patrick M. Boyle, Sneha Manikandan, Jie Zheng, Sherwin Ng, Clifford G. Robinson, Phillip S. Cuculich, Geoffrey D. Hugo, Julie K. Schwarz, Stephanie N. Hicks, Timothy W. Smith, Leslie Dawn Wilson, Nels Knutson, Caleb Berberet, James Tabor

May 20, 2025article en

3 citations

STAR Locally Prolongs Effective Refractory Period and Increases Ventricular Tachycardia Cycle Length Without Short-Term Scar Formation or Functional Decline: Insights From a Translational Porcine Model Study

Authors

Institutions

Publication Details

STAR Locally Prolongs Effective Refractory Period and Increases Ventricular Tachycardia Cycle Length Without Short-Term Scar Formation or Functional Decline: Insights From a Translational Porcine Model Study

STAR Locally Prolongs Effective Refractory Period and Increases Ventricular Tachycardia Cycle Length Without Short-Term Scar Formation or Functional Decline: Insights From a Translational Porcine Model Study

Abstract

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