Localised Epidermolysis Bullosa Simplex in Mono-Zygotic Twins

Epidermolysis bullosa simplex is a rare blistering disorder without any curable treatments, mainly inherited in an Autosomal Dominant fashion. It is even rarer in twins. It is characterised by cutaneous fragility and blister formation after minimal trauma. It typically presents with localised, mild, acral blistering and normal life expectancy. Its localised presentation, confined to the palms and soles and association with punctuate callosities, may lead to misdiagnosis of Palmoplantar warts. We report two cases of localised EBS occurring in mono-zygotic twins with no family history.