Spleen-Heart Cross-Talk Through CD23-Mediated Signal Promotes Cardiac Remodeling
Our findings indicate a critical role of the Ltf-ADAM10-CD23 axis in regulating IgE production through cross-talk between the heart and spleen. The Ltf-ADAM10-CD23 axis may represent new molecular targets for IgE-mediated pathological cardiac remodeling.
Authors
- Chi Geng (ORCID: https://orcid.org/0000-0002-9737-7271)
- Yunfei Xue (ORCID: https://orcid.org/0000-0001-6871-8228)
- Yarong Zhang
- Junye Chen (ORCID: https://orcid.org/0000-0001-9224-1677)
- Yingge Zhang
- Jing Wang (ORCID: https://orcid.org/0000-0003-2410-5408)
- Yang Yang (ORCID: https://orcid.org/0000-0002-8392-2830)
- Zhiwei Li (ORCID: https://orcid.org/0000-0001-8031-6547)
- Qian Chen (ORCID: https://orcid.org/0000-0002-1487-5479)
- Shan Jin (ORCID: https://orcid.org/0000-0002-6268-1759)
- Hongqin Yang (ORCID: https://orcid.org/0009-0008-8764-172X)
- Jiaxin Zhang (ORCID: https://orcid.org/0009-0004-7652-8191)
- Y P Feng
- Kegang Jia
- Hongmei Zhao (ORCID: https://orcid.org/0009-0007-3908-3316)
Institutions
- Oklahoma State Department of Health (US)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- State Administration of Traditional Chinese Medicine of the People's Republic of China (CN)
- TEDA International Cardiovascular Hospital (CN)
Publication Details
- Journal
- Circulation Research
- Published
- 2025-05-20
- DOI
- https://doi.org/10.1161/circresaha.124.325813
- Citations
- 2
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 2.78