Storage Time and DNA Quality Determine BRCA1/2 Sequencing Success in Prostate Cancer: A Multicentre Analysis with Therapeutic Implications
Timely testing of <i>BRCA1</i>/2 mutations is critical for optimizing the identification of prostate cancer patients eligible for PARP inhibitors. Surgical specimens provide more reliable results than biopsies and minimizing the storage duration significantly enhances testing outcomes. Standardizing pre-analytical and laboratory procedures across centres is essential to ensure personalized treatments and improve patient outcomes.
Authors
- Sara Gaeta
- Andrea Vecchione (ORCID: https://orcid.org/0000-0002-5497-6856)
- Davide Seminati (ORCID: https://orcid.org/0000-0002-2166-301X)
- Elisa Melucci (ORCID: https://orcid.org/0000-0003-4908-5271)
- Stefania Tommasi (ORCID: https://orcid.org/0000-0002-2157-2978)
- Umberto Malapelle (ORCID: https://orcid.org/0000-0003-3211-9957)
- Mariavittoria Vescovo (ORCID: https://orcid.org/0000-0001-6959-3252)
- Maria Rosaria Raspollini (ORCID: https://orcid.org/0000-0001-6630-4881)
- Beatrice Casini (ORCID: https://orcid.org/0000-0002-9038-0179)
- Francesca Giunchi
- Eleonora Nardi (ORCID: https://orcid.org/0000-0002-8408-7646)
- Giancarlo Troncone (ORCID: https://orcid.org/0000-0003-1630-5805)
- Alessandra Rappa (ORCID: https://orcid.org/0000-0001-9180-4757)
- Francesca Castiglione (ORCID: https://orcid.org/0000-0003-1696-5651)
- Stefania Scarpino (ORCID: https://orcid.org/0009-0009-9668-9626)
- Mariantonia Carosi (ORCID: https://orcid.org/0000-0002-6298-7168)
- Matteo Fassan (ORCID: https://orcid.org/0000-0001-6515-5482)
- Fabio Pagni (ORCID: https://orcid.org/0000-0001-9625-1637)
- Dario de Biase (ORCID: https://orcid.org/0000-0002-0609-8817)
- Giuseppe Perrone (ORCID: https://orcid.org/0000-0002-9538-5729)
- Lorenzo Nibid (ORCID: https://orcid.org/0000-0001-8583-0596)
- Luisa Toffolatti
- Francesco Massari (ORCID: https://orcid.org/0000-0001-6476-6871)
- Chiara Taffon
- Francesco Pepe (ORCID: https://orcid.org/0000-0002-2803-9586)
- Francesco Prata (ORCID: https://orcid.org/0000-0003-3084-6210)
- Alessandro Caputo (ORCID: https://orcid.org/0000-0001-5139-3869)
- Pio Zeppa (ORCID: https://orcid.org/0000-0001-7358-5925)
- Elena Guerini-Rocco
- Daniela Righi (ORCID: https://orcid.org/0000-0001-8014-6779)
- C. Coppola (ORCID: https://orcid.org/0009-0009-1705-7875)
- Federica Conversano
Institutions
- University of Salerno (IT)
- University of Padua (IT)
- Università Campus Bio-Medico (IT)
- University of Milan (IT)
- Istituto Oncologico Veneto (IT)
- Azienda Ospedaliero-Universitaria Careggi (IT)
- Azienda USL di Bologna (IT)
- Istituto Tumori Bari (IT)
- Campus Bio Medico University Hospital (IT)
- Ca' Foncello Hospital (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- European Institute of Oncology (IT)
- University of Milano-Bicocca (IT)
- University of Bologna (IT)
Publication Details
- Journal
- Cancers
- Published
- 2025-05-20
- DOI
- https://doi.org/10.3390/cancers17101705
- Citations
- 3
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 4.56