Determining Drug Exposure Based on Medication Dispensing Data: A Validation Study of Vitamin K Antagonist Treatment Episodes Against <scp>INR</scp> Records
Fixed methods performed better than dynamic methods when classifying VKA exposure based on dispensing data. Our findings may guide other researchers working with VKA dispensing data, especially when the tablets dispensed or the prescribed dose are unavailable.
Authors
- Anne Gulbech Ording (ORCID: https://orcid.org/0000-0002-8073-7664)
- Carline van den Dries
- Suzanne C. Cannegieter (ORCID: https://orcid.org/0000-0003-4707-2303)
- Chantal Visser (ORCID: https://orcid.org/0000-0002-2025-1734)
- Johanneke E.A. Portielje (ORCID: https://orcid.org/0000-0002-5169-6306)
- Qingui Chen (ORCID: https://orcid.org/0000-0001-9669-0007)
- Melchior C. Nierman (ORCID: https://orcid.org/0000-0002-8647-7509)
- Eric C. T. Geijteman (ORCID: https://orcid.org/0000-0001-7354-2220)
- Sarah J Aldridge (ORCID: https://orcid.org/0000-0002-5158-1242)
- Eva K Kempers (ORCID: https://orcid.org/0000-0001-9458-8674)
- Frederikus Albertus Klok (ORCID: https://orcid.org/0000-0001-9961-0754)
- Sjef J. C. M. van de Leur
- Kate Lifford (ORCID: https://orcid.org/0000-0002-9782-2080)
- Mette Søgaard (ORCID: https://orcid.org/0000-0002-2830-4968)
- Denise Abbel (ORCID: https://orcid.org/0000-0002-7111-6604)
- Jamilla Goedegebuur (ORCID: https://orcid.org/0000-0001-9571-7431)
- Marieke J.H.A. Kruip
- Annelies Boetes‐Draisma
Institutions
- Utrecht University (NL)
- Aalborg University Hospital (DK)
- Leiden University Medical Center (NL)
- Erasmus MC (NL)
- University Medical Center Utrecht (NL)
- Swansea University (GB)
- Isala (NL)
- Erasmus MC Cancer Institute (NL)
- Star Medisch Diagnostisch Centrum (NL)
- Cardiff University (GB)
- Cardiff Metropolitan University (GB)
- Aalborg University (DK)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- Pharmacoepidemiology and Drug Safety
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1002/pds.70158
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00