The impact of obesity and weight loss treatment on metabolic parameters, cardiovascular autonomic and sensory nerve function and in vitro fertilization outcomes in infertile women: a pilot study
Peripheral sensory neuronal impairments were detected in infertile women with obesity compared to the controls with normal BMI. Cardiovascular autonomic dysfunction was revealed by 30/15 and Valsalva-ratio in patients with obesity, suggesting the presence of parasympathetic dysfunction. Preconceptional weight loss improved metabolic parameters. Of the infertile female patients with obesity who reached their preconceptional target weight, 18.75% achieved spontaneous pregnancy without IVF, and 62.5% of those who underwent IVF successfully conceived.
Authors
- Csaba Lengyel
- István Baczkó (ORCID: https://orcid.org/0000-0002-9588-0797)
- Anna Vágvölgyi (ORCID: https://orcid.org/0000-0002-8810-700X)
- János Zádori (ORCID: https://orcid.org/0000-0002-2560-2118)
- Viktor Vedelek (ORCID: https://orcid.org/0000-0002-0420-8226)
- Attila Nemes (ORCID: https://orcid.org/0000-0002-7570-6214)
- Adrienn Menyhárt (ORCID: https://orcid.org/0009-0008-8613-2341)
- Tamás Várkonyi (ORCID: https://orcid.org/0000-0003-2057-7993)
- Szilvia Lada (ORCID: https://orcid.org/0009-0001-9556-4778)
- Péter Kempler (ORCID: https://orcid.org/0000-0002-6072-8832)
- Nóra Keller
- Dalma Szöllősi
Institutions
- Semmelweis University (HU)
- University of Szeged (HU)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-05-20
- DOI
- https://doi.org/10.3389/fendo.2025.1548587
- Primary Topic
- Pharmacology and Obesity Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Nemzeti Kutatási Fejlesztési és Innovációs Hivatal
- Szegedi Tudományegyetem
- National Research, Development and Innovation Office