Meeting report: DMDG peptide and oligonucleotide ADME workshop 2024
2. The following topics were covered:Metabolism of conjugated peptides & proteinsStrategies for increased metabolic stability of peptidesIQ's take on metabolism & excretion studies for peptidesDMPK challenges related to oligonucleotides during developmentImaging of oligonucleotidesIdentification of extrahepatic targets of oligonucleotidesIn vitro systems for metabolism studies of oligonucleotidesNovel hybridisation LC-MS/MS approach for quantitative analysis of oligonucleotidesPKPD, PBPK & modelling.
Authors
- Bo Lindmark (ORCID: https://orcid.org/0000-0002-4708-8797)
- Jesper Kammersgaard Christensen
- Inga Bjørnsdottir (ORCID: https://orcid.org/0000-0002-1249-4920)
- Steve R. Hood (ORCID: https://orcid.org/0000-0002-7708-7699)
- Ralf Lotz
Institutions
- Novo Nordisk (Denmark) (DK)
- GlaxoSmithKline (India) (IN)
- AstraZeneca (Brazil) (BR)
- Boehringer Ingelheim (India) (IN)
Publication Details
- Journal
- Xenobiotica
- Published
- 2025-04-21
- DOI
- https://doi.org/10.1080/00498254.2025.2506702
- Primary Topic
- Spectroscopy Techniques in Biomedical and Chemical Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00