Exploring the mediating effects of amino acids on BMI and gestational diabetes mellitus: a longitudinal population-based cohort study
Amino acid metabolism is correlated with BMI, GDM, and glucose levels. Notably, BMI and GDM/glucose intolerance are significantly mediated by alanine and leucine levels. This suggests a new way to study why overweight or obese mothers are more likely to develop GDM and glucose intolerance.
Authors
- Gengdong Chen (ORCID: https://orcid.org/0000-0001-7180-8099)
- Xiaoyan Gou
- Zixing Zhou (ORCID: https://orcid.org/0000-0002-2180-6471)
- Zhengping Liu (ORCID: https://orcid.org/0000-0002-4964-0258)
- Dandan Yu (ORCID: https://orcid.org/0000-0001-9567-8647)
- Pengsheng Li (ORCID: https://orcid.org/0000-0002-7015-5273)
- Xiangdong Yang (ORCID: https://orcid.org/0000-0001-7355-6569)
- Dazhi Fan (ORCID: https://orcid.org/0000-0003-2773-9166)
- Haiyan Wang (ORCID: https://orcid.org/0000-0002-5204-967X)
- Lijuan Wang (ORCID: https://orcid.org/0000-0003-1727-2670)
- Fang Huang
- Dongmei Suo
Institutions
- Foshan Maternity and Child Health Care Hospital (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-05-20
- DOI
- https://doi.org/10.3389/fendo.2025.1502678
- Citations
- 2
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 6.99
Funders
- Guangdong Medical Research Foundation