Regional cerebral blood flow in a patient with restless legs syndrome exhibiting pramipexole‐induced hypersexuality

This case suggests that pramipexole-induced hypersexuality in RLS may be linked to increased rCBF within the mesocorticolimbic network, including orbitofrontal cortex, medial frontal cortex, and striatum, thereby impairing impulse control. Despite the relatively low dose of pramipexole (0.5 mg/day), individual susceptibility factors, such as depressive symptoms and intellectual disability, may have contributed to ICD onset. Given the lack of prior studies examining rCBF in RLS patients with ICDs, further research is needed to elucidate the pathophysiological mechanisms and risk factors associated with pramipexole-induced ICDs in RLS.