Optimized expression of oxazolomycins in engineered Streptomyces longshengensis and their activity evaluation
An oxazolomycin high-producing system of S. longshengensis was established by employing genetic engineering strategies to facilitate the bioactivity exploitation. Oxazolomycin Toxa5 showed interesting inhibitory effects against multiple Gram-negative and -positive pathogens as well as antioxidant capacity, indicating its great potential in clinical applications. The findings provide an efficient strategy for the overproduction and activity evaluation of oxazolomycins.
Authors
- Xiang Liu (ORCID: https://orcid.org/0000-0002-9372-9110)
- Yang Xu (ORCID: https://orcid.org/0000-0001-7587-2194)
- Junyue Li
- Yue Li (ORCID: https://orcid.org/0000-0003-1557-3568)
- Jihui Zhang (ORCID: https://orcid.org/0000-0002-3252-316X)
- Yuqing Tian
- Huarong Tan (ORCID: https://orcid.org/0000-0002-8842-9092)
- Huiying Sun
Institutions
- Institute of Mechanics (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Microbial Cell Factories
- Published
- 2025-05-20
- DOI
- https://doi.org/10.1186/s12934-025-02726-9
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- National Key Research and Development Program of China
- Institute of Microbiology, Chinese Academy of Sciences