Research Progress in Biologic Agents for Treating Autoimmune Diseases in Children

自身免疫性疾病(Autoimmune diseases, AIDs)是一组免疫系统对自身抗原产生持续迁延的免疫应答的疾病。近年来，儿童自身免疫性疾病的发病率逐渐升高，危害儿童身体健康。传统治疗方案以糖皮质激素和免疫抑制剂为主，但部分患者治疗后疾病控制效果不佳、复发率高。随着生物制剂在临床上的应用，AIDs患者的治疗效果在一定程度上得到了改善。本文阐述AIDs种生物制剂的治疗现状与进展，对临床医生精准施用方案、控制患儿病情、改善治疗效果及预后等方面具有深远意义。Autoimmune diseases (AIDs) are a group of disorders characterized by persistent and prolonged immune responses against self-antigens. In recent years, the incidence of autoimmune diseases in children has gradually increased, posing significant risks to their health. Traditional treatment regimens primarily rely on glucocorticoids and immunosuppressants, but some patients exhibit poor disease control and high relapse rates after therapy. With the clinical application of biologic agents, the therapeutic outcomes for AIDs patients have improved to some extent. This article reviews the current status and advances in biological therapies for AIDs, which holds profound implications for clinicians in optimizing treatment strategies, achieving disease control, improving therapeutic efficacy, and enhancing prognosis in pediatric patients.