Exploring the mechanism by which UCHL3 alleviates diabetic foot ulcers: FOXM1/NLRP3 inflammasome-mediated angiogenesis and endothelial cell pyroptosis
UCHL3 enhances FOXM1 deubiquitination, inhibits NLRP3 inflammasome activation, and reduces EC pyroptosis, thereby contributing to DFU healing. UCHL3 and FOXM1 are potential therapeutic targets for DFU.
Authors
- Xincheng Liao (ORCID: https://orcid.org/0000-0001-5388-5971)
- Guanghua Guo
- Zhonghua Fu
- Zhengying Jiang
Institutions
- First Affiliated Hospital of Jiangxi Medical College (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2025-05-20
- DOI
- https://doi.org/10.1186/s13018-025-05914-w
- Primary Topic
- Diabetic Foot Ulcer Assessment and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China