Association of psychosocial factors and biological pathways identified from rare-variant analysis with longitudinal trajectories of treatment response in major depressive disorder
Our findings suggest that patients exhibiting a fluctuating response to antidepressant treatment may endure more severe clinical symptoms throughout the treatment course. The involvement of the neurotrophin signaling pathway and TRP channels in these response patterns highlights their potential as novel targets for therapeutic intervention in depression. This underscores the importance of personalized treatment strategies that consider the underlying genetic and psychological factors influencing antidepressant efficacy.
Authors
- Chenjie Gao (ORCID: https://orcid.org/0000-0002-4010-1186)
- Wenji Chen
- Zhi Xu (ORCID: https://orcid.org/0000-0003-0784-1702)
- Yonggui Yuan (ORCID: https://orcid.org/0000-0001-6496-3998)
- Chunyu Liu (ORCID: https://orcid.org/0000-0002-7178-6712)
- Yufan Cai
- Yan Xia (ORCID: https://orcid.org/0000-0001-5204-9701)
- Zhijun Zhang (ORCID: https://orcid.org/0000-0003-4538-8187)
- Haiping Tang
- Yongqi Shao
Institutions
- Central South University (CN)
- SUNY Upstate Medical University (US)
- Yale University (US)
- Zhongda Hospital Southeast University (CN)
- Southeast University (CN)
Publication Details
- Journal
- BMC Psychiatry
- Published
- 2025-05-20
- DOI
- https://doi.org/10.1186/s12888-025-06895-0
- Citations
- 3
- Primary Topic
- Treatment of Major Depression
- Type
- article
- Field-Weighted Citation Impact
- 4.18
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Southeast University
- Science and Technology Planning Project of Guangdong Province