Induction of more severe central sensitization in a medication overuse headache model mice through active ingestion of rizatriptan
This study pioneers an ethologically valid MOH model that reflects more severe central sensitization and recapitulates active medication-seeking behaviour. PrL-mediated addiction-like-behaviour pathways and SPVC-centred nociceptive processing may play roles in the development of MOH. These findings provide novel neuromodulation targets (PrL, IC, SPVC) for refractory MOH management.
Authors
- Ruozhuo Liu (ORCID: https://orcid.org/0000-0001-8582-580X)
- Zhenjie Ma
- Wenjing Tang (ORCID: https://orcid.org/0000-0003-2312-1000)
- Dong Zhao (ORCID: https://orcid.org/0000-0001-7214-6947)
- Wei Xie (ORCID: https://orcid.org/0000-0002-9179-4787)
- Cancan Chen (ORCID: https://orcid.org/0000-0002-5797-8988)
- Chenhao Li (ORCID: https://orcid.org/0000-0003-1182-6804)
- Wenhao Bai
- Wenwen Zhang (ORCID: https://orcid.org/0000-0003-2443-3559)
- Yang Li (ORCID: https://orcid.org/0000-0002-2853-8916)
- Xiao Han (ORCID: https://orcid.org/0000-0003-3787-3529)
- Dengfa Zhao
- Yingyuan Liu
- Mingjie Zhang (ORCID: https://orcid.org/0000-0003-1267-876X)
- Shengyuan Yu
- Deqi Zhai
Institutions
- Chinese PLA General Hospital (CN)
- Aerospace Center Hospital (CN)
- Chinese People's Liberation Army (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- The Journal of Headache and Pain
- Published
- 2025-05-20
- DOI
- https://doi.org/10.1186/s10194-025-02066-4
- Citations
- 4
- Primary Topic
- Migraine and Headache Studies
- Type
- article
- Field-Weighted Citation Impact
- 5.88
Funders
- National Natural Science Foundation of China