BIOCHEMICAL MARKERS OF OXIDATIVE STRESS AT THE PATIENTS WITH PURULENT-DESTRUCTIVE DISEASES OF LUNGS AND PLEURA

The article contains information related to the mechanism of purulent process development in lungs and pleura, development of oxidative stress within the organism of patients with purulent-destructive diseases of lungs and pleura, usage of combination of two methodics of ozontherapy. Investigation of biochemical markers is suggested for confirmation of effectiveness of ozontherapy in diagnostics and treatment of oxidative stress at patients with purulent-destructive diseases of lungs and pleura. Increasing of oxygen deficiency leading to more manifesting tissues resistance decreasing to infection statistically is demonstrated, all that creates precondition to inflammation progressing within the lungs and pleura. In turn it leads to even greater oxygen level decreasing in blood due to gas exchange disturbance. Comparative estimation of effectiveness of ozontherapy complex treatment comparing with traditional method of abscesses and empyemas treatment is performed. Conclusions: Lots of metabolic reactions happen in the organism of patient with purulent-destructive disease of lungs and pleura, with oxidative stress developing, coming out of proinflammatory cytokines in a big amount, damaging of endothelium of vessels, developing of immunopathological reactions.