EFFECTS OF NASVAI ON THE LEVEL OF TOTAL PLASMA PROTEIN IN EXPERIMENTAL ANIMALS

This article examines the epidemiology and prevalence, as well as the effect on the body of smokeless tobacco products. One of the most common forms of use of smokeless tobacco products is nasvai. This type of smokeless tobacco is widely used in Pakistan, Afghanistan and Central Asia (in countries such as Uzbekistan, Tajikistan, Kyrgyzstan, Turkmenistan and Kazakhstan). Nasvai has not yet been recognized as carcinogenic by the International Agency for Research on Cancer (IARC), partly due to a lack of evidence and a link between nasvai use and the occurrence of malignant neoplasms. In addition, non-smoking tobacco, both in Pakistan and in other Central Asian countries, is not yet regulated and taxed, as a result of which it is freely available to both adults and children compared to cigarettes. Due to the relevance of the topic and the increase in the consumption of smokeless tobacco products, experimental work was carried out on laboratory rats in the amount of 100 male individuals, divided into two groups: an experimental group and a control group. As a result of the study, it was concluded that nasvai negatively affects the synthetic function of the liver, as a result of which the level of total protein in the blood plasma of laboratory animals was sharply reduced on the 60th day of the experiment, which is a manifestation of hypoproteinemia.