Clinicopathologic Features, Management, and Outcomes Of Pediatric <i>CRTC1::TRIM11</i> and <i>MED15::ATF1</i> Tumors With Spitzoid Morphology: A Case Series
Limited information is available on the clinicopathologic features and management of pediatric CRTC1::TRIM11 (CTRTs) and MED15::ATF1-rearranged tumors (MARTs). In this series of pediatric CTRTs (n = 5) and MARTs (n = 2), all tumors exhibited spitzoid morphology and expressed melanocytic markers. Metastatic progression occurred in one CTRT and two MARTs: all three received immunotherapy, resulting in disease control in two patients and one death due to progressive disease. A fourth individual had lymph node micrometastasis that remained stable without progression. This case series highlights the potentially aggressive behavior of these tumors and suggests that immunotherapy may be an effective treatment option for advanced disease.
Authors
- Ina Lee (ORCID: https://orcid.org/0000-0002-6082-6395)
- Mary Frances Wedekind (ORCID: https://orcid.org/0000-0001-9707-7175)
- Andrea M. Gross (ORCID: https://orcid.org/0000-0003-1646-4531)
- Svetlana Pack (ORCID: https://orcid.org/0000-0003-3256-6626)
- Rosandra N. Kaplan (ORCID: https://orcid.org/0000-0002-8580-0001)
- Marielle E. Yohe (ORCID: https://orcid.org/0000-0001-5356-9426)
- Mark Raffeld (ORCID: https://orcid.org/0000-0002-4039-6957)
- Frederic G. Barr (ORCID: https://orcid.org/0000-0002-1051-7447)
- Christina K. Ferrone (ORCID: https://orcid.org/0000-0001-9309-2132)
- Allison Close (ORCID: https://orcid.org/0000-0002-0976-4723)
- Liqiang Xi (ORCID: https://orcid.org/0000-0001-5033-7072)
- Ruth M. Pfeiffer (ORCID: https://orcid.org/0000-0001-7791-2698)
- Kmc Cheung (ORCID: https://orcid.org/0000-0002-0048-5576)
- Faizan Malik (ORCID: https://orcid.org/0000-0001-8597-5074)
- Alberto S. Pappo (ORCID: https://orcid.org/0000-0002-5338-3979)
- Michael R. Sargen (ORCID: https://orcid.org/0000-0003-1039-2522)
- Kristen G. Berrebi (ORCID: https://orcid.org/0000-0001-8537-3647)
- Alisa M. Goldstein (ORCID: https://orcid.org/0000-0002-7538-3582)
- Kenneth Aldape (ORCID: https://orcid.org/0000-0001-5119-7550)
- Armita Bahrami (ORCID: https://orcid.org/0000-0002-8515-2649)
- Jeffrey Gagan (ORCID: https://orcid.org/0000-0003-4676-9969)
- Larissa V. Furtado (ORCID: https://orcid.org/0000-0001-7784-9502)
- Brigitte C. Widemann (ORCID: https://orcid.org/0000-0002-9198-7175)
- Brittani Seynnaeve (ORCID: https://orcid.org/0000-0001-5011-7678)
- Anna Hayden (ORCID: https://orcid.org/0000-0001-9762-7261)
- Stephen M. Hewitt
- Jennifer S. Ko (ORCID: https://orcid.org/0000-0003-0629-775X)
- Madeline H. Fitzhugh
- S. Horton
- Jessica N. Hatton (ORCID: https://orcid.org/0000-0003-2104-171X)
- Vincent Liu (ORCID: https://orcid.org/0000-0003-1987-9521)
Institutions
- National Institutes of Health (US)
- St. Jude Children's Research Hospital (US)
- Cleveland Clinic (US)
- University of Louisville (US)
- Emory University (US)
- University of Pittsburgh (US)
- University of Iowa Hospitals and Clinics (US)
- University of Iowa Stead Family Children’s Hospital (US)
- Helen DeVos Children's Hospital (US)
- National Cancer Institute (US)
- Center for Cancer Research (US)
Publication Details
- Journal
- Pediatric Blood & Cancer
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1002/pbc.31814
- Citations
- 5
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 3.99
Funders
- National Institutes of Health
- National Cancer Institute