Engineered celastrol liposomes with glycyrrhizic acid augment synergistic antitumor efficacy in breast cancer
GA/LIP-CEL combines GA's membrane-targeting capabilities with CEL's therapeutic effects, improving stability, specificity, and safety. This platform represents a novel strategy for precision drug delivery, addressing limitations of conventional systems through natural component integration. Further validation of <i>in vivo</i> performance and pharmacokinetics is warranted to advance clinical translation.
Authors
- Hong Liang (ORCID: https://orcid.org/0000-0001-9015-3358)
- Liling Yue (ORCID: https://orcid.org/0000-0002-6041-821X)
- Wei Zhang (ORCID: https://orcid.org/0000-0002-2235-1851)
- Jiping Li (ORCID: https://orcid.org/0000-0003-2868-2456)
- Xiuli Gao (ORCID: https://orcid.org/0000-0003-3012-4373)
- Likun Liu (ORCID: https://orcid.org/0000-0002-7016-7530)
Institutions
- Qiqihar Medical University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-05-20
- DOI
- https://doi.org/10.3389/fonc.2025.1602585
- Citations
- 1
- Primary Topic
- Pharmacological Effects of Natural Compounds
- Type
- article
- Field-Weighted Citation Impact
- 1.56
Funders
- Health Commission of Heilongjiang Province