Humoral and cellular immune responses in cattle upon Clostridium chauvoei vaccination and challenge
These findings demonstrate a coordinated interplay between humoral and cellular immune responses in vaccine-induced protection, with IFN-γ emerging as a potential biomarker in conjunction with antibody titre. The study provides a deeper further understanding on the immune mechanisms underlying vaccine-mediated protection against <i>C. chauvoei</i> and shall be relevant for the development of more effective vaccines.
Authors
- Julio Guarnaschelli
- María Moreno (ORCID: https://orcid.org/0000-0002-6218-5501)
- Andrés Iriarte (ORCID: https://orcid.org/0000-0002-5862-0152)
- José A. Chabalgoity (ORCID: https://orcid.org/0000-0002-1759-228X)
- Analía Rial (ORCID: https://orcid.org/0000-0002-9590-1316)
- Andrea Rossi (ORCID: https://orcid.org/0000-0001-8575-700X)
- Mariana Rivera-Patron (ORCID: https://orcid.org/0000-0003-1480-0992)
Institutions
- Universidad de la República de Uruguay (UY)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-20
- DOI
- https://doi.org/10.3389/fimmu.2025.1584168
- Citations
- 2
- Primary Topic
- Clostridium difficile and Clostridium perfringens research
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- Universidad de la República Uruguay
- Comisión Sectorial de Investigación Científica