Influence of programmed death ligand 1 (PD-L1) knockout on gut microbiota in experimental autoimmune uveitis
Both EAU and PD-L1 knockout modulate gut microbiota, affecting microbial composition - particularly <i>Akkermansia</i>, <i>CAG-485</i>, Bacteroidaceae, Lachnospiraceae and Ruminococcaceae - and microbial functions such as lipid, carbohydrate and glycan metabolism.
Authors
- Qing Chang (ORCID: https://orcid.org/0000-0001-5138-8760)
- Junxiang Gu (ORCID: https://orcid.org/0000-0002-3420-2247)
- Ling Chen (ORCID: https://orcid.org/0000-0001-8604-6808)
- Yi Ma (ORCID: https://orcid.org/0000-0002-3781-314X)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Eye & ENT Hospital of Fudan University (CN)
- Shandong Eye Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-20
- DOI
- https://doi.org/10.3389/fimmu.2025.1600673
- Citations
- 1
- Primary Topic
- Ocular Diseases and Behçet’s Syndrome
- Type
- article
- Field-Weighted Citation Impact
- 1.71
Funders
- Shanghai Science and Technology Development Foundation
- National Natural Science Foundation of China
- Shanghai Hospital Development Center