YY1-induced DDX18 modulates EMT via the AKT/mTOR pathway in esophageal cancer: a novel therapeutic target
The transcription of DDX18 was activated by YY1, and DDX18 promoted tumor cell growth and EMT through the AKT/mTOR signaling pathway in esophageal cancer cells.
Authors
- Rui Wang (ORCID: https://orcid.org/0000-0003-0773-2127)
- Tianyu Lu (ORCID: https://orcid.org/0000-0002-7958-1594)
- Xiaochao Ma (ORCID: https://orcid.org/0000-0003-2049-7467)
- Yulu He (ORCID: https://orcid.org/0000-0002-2531-1521)
- Youbin Cui
- Yue Yang
- Ze Tang
Institutions
- Jilin University (CN)
- First Hospital of Jilin University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-05-20
- DOI
- https://doi.org/10.1186/s12967-025-06555-7
- Citations
- 2
- Primary Topic
- Cancer-related gene regulation
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Department of Science and Technology of Jilin Province
- Jilin Scientific and Technological Development Program