About Two Rare Neoplasms of the Gastrointestinal Tract: Multicentric Epitheliod Angiosarcoma of Small Bowel and Symplastic PeComa of Colon - A Case Report and Literature Review

Two cases of rare gastrointestinal pathology are presented.The first concerns a 66-year-old man hospitalized for severe intestinal hemorrhage and hemoperitoneum.He presents multiple nodular lesions involving the jejunum and ileum.The histological and immunohistochemical findings lead to the diagnosis of Multicentric Epithelioid Angiosarcoma.Variant of angiosarcoma peculiar to the gastrointestinal tract, with particular clinical-pathological characteristics The second concerns a 66-year-old man was admitted to hospital with symptoms of intestinal obstruction.The endoscopic examination revealed a large polypoid neoformation obstructing the lumen of the right colon.The combination of histological and immunophenotypic data of the intraluminal polypoid neoformation leads to the conclusion that the diagnosis of PeComa is consistent.The neoplasm presents some particular characteristics represented by the presence of bizarre, nucleolated and multinucleated elements with sometimes rhabdomoblastic-like aspects which has led to an in-depth differential diagnostic evaluation.The current literature at the moment does not offer concrete data for the nosographic and prognostic positioning of these morphological features.