Single-cell transcriptomics in colorectal cancer uncover the potential of metastasis and immune dysregulation of a cell cluster overexpressed PRSS22
Our study has identified a cell subcluster that is closely linked to progression, immune dysregulation and prognosis in CRC, and we have also identified <i>PRSS22</i> as its hub gene that has great potential to become a new immunotherapeutic targets target for CRC.
Authors
- Shoubin Zhong
- Chengyuan Xu (ORCID: https://orcid.org/0000-0002-2149-9934)
- Zhenhua Li (ORCID: https://orcid.org/0000-0001-6327-9561)
- Qingyun Zhang
- Dongfei Zhu
- Ziheng Zhou (ORCID: https://orcid.org/0000-0002-0374-1838)
Institutions
- Tongji University (CN)
- Weifang Medical University (CN)
- Weifang People's Hospital (CN)
- Shanghai Sixth People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-20
- DOI
- https://doi.org/10.3389/fimmu.2025.1586428
- Citations
- 5
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 5.23