Design of colloidal vectors for active targeting <i>via</i> complexation of biotinylated copolymers with gadolinium ions
This study presents the design of biotin-functionalized hybrid polyionic complexes (HPICs) using RAFT polymers for MRI applications. The synthesized colloidal vectors, complexed with gadolinium ions, demonstrate high stability, relaxivity, and biotin accessibility for active targeting. Preliminary <i>in vivo</i> studies confirm their potential for improved MRI contrast and pharmacokinetic tracking.
Authors
- Mathias Destarac (ORCID: https://orcid.org/0000-0002-9718-2239)
- Maksym Odnoroh (ORCID: https://orcid.org/0000-0001-9177-5730)
- Olivier Coutelier (ORCID: https://orcid.org/0000-0002-1397-3165)
- Carine Pestourie (ORCID: https://orcid.org/0000-0002-3877-6897)
- Franck Desmoulin (ORCID: https://orcid.org/0000-0003-0560-6266)
- Christophe Mingotaud (ORCID: https://orcid.org/0000-0002-9651-6209)
- Jean‐Daniel Marty (ORCID: https://orcid.org/0000-0001-7631-8865)
Institutions
- Centre National de la Recherche Scientifique (FR)
- Université Toulouse III - Paul Sabatier (FR)
- Inserm (FR)
- École Nationale Vétérinaire de Toulouse (FR)
- Université Fédérale de Toulouse Midi-Pyrénées (FR)
Publication Details
- Journal
- Nanoscale
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5nr00986c
- Citations
- 3
- Primary Topic
- Biotin and Related Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.45
Funders
- Agence Nationale de la Recherche