Reverse vaccinology-based design of multivalent multiepitope mRNA vaccines targeting key viral proteins of Herpes Simplex Virus type-2
The rationally designed multiepitope mRNA vaccine constructs exhibit strong antigenic potential, structural stability, and immune-stimulatory properties, positioning them as promising candidates for HSV-2 vaccine development. These findings offer a novel, safe, and effective approach to HSV-2 immunization, warranting further experimental validation and preclinical studies.
Authors
- Anwesha Banerjee (ORCID: https://orcid.org/0000-0002-2671-4074)
- Anupam Mukherjee (ORCID: https://orcid.org/0000-0002-0612-2258)
- Kishore Dhotre (ORCID: https://orcid.org/0000-0002-4728-8553)
- Nikhat J. Siddiqi (ORCID: https://orcid.org/0000-0002-4830-3217)
- Vijay Nema (ORCID: https://orcid.org/0000-0001-6420-9397)
- Abdul Arif Khan (ORCID: https://orcid.org/0000-0002-8748-1841)
- Pratik Mahajan
- Manali Joshi (ORCID: https://orcid.org/0000-0002-4255-2474)
- Abdul Malik (ORCID: https://orcid.org/0000-0001-6369-4298)
- Debashree Dass (ORCID: https://orcid.org/0009-0001-8264-0065)
- N S Suneesh
Institutions
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- King Saud University (SA)
- National Institute for Research in Tribal Health (IN)
- National AIDS Research Institute (IN)
- ICMR-National Institute of Virology (IN)
- Savitribai Phule Pune University (IN)
- Academy of Scientific and Innovative Research (IN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-20
- DOI
- https://doi.org/10.3389/fimmu.2025.1586271
- Citations
- 3
- Primary Topic
- Herpesvirus Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.06
Funders
- Arthritis National Research Foundation
- National Research Foundation
- Department of Biotechnology, Ministry of Science and Technology, India
- Department of Science and Technology, Ministry of Science and Technology, India
- Indian Council of Medical Research
- King Saud University
- Savitribai Phule Pune University