Deletion of Mex3c gene leads to autistic-like behavior in mice by inhibiting AMPK signal pathway

Our findings suggest that <i>Mex3c</i> gene deletion induces ASD-like phenotypes in mice, potentially through disruption of mitochondrial function and synaptic integrity via the AMPK/SIRT1/PGC1? pathway. These results support the candidacy of <i>Mex3c</i> as a susceptibility gene for ASD and highlight mitochondrial signaling pathways as potential therapeutic targets.