Characterisation of the novel quinoline RCD405: Relaxant effects on cholinergic and histaminergic tone in human bronchi and small airways
RCD405 showed significant potential as a novel bronchodilator drug for the treatment of asthma and COPD through its ability to induce relaxation of hASM. These findings suggest that further investigation of RCD405 is warranted as a possible novel treatment of chronic respiratory disorders.
Authors
- Luigino Calzetta (ORCID: https://orcid.org/0000-0003-0456-069X)
- Paola Rogliani (ORCID: https://orcid.org/0000-0001-7801-5040)
- Mia Lundblad
- Francesco Facciolo (ORCID: https://orcid.org/0000-0002-7137-8946)
- Clive Page (ORCID: https://orcid.org/0000-0002-9358-3799)
Institutions
- University of Rome Tor Vergata (IT)
- University of Parma (IT)
- King's College London (GB)
- Medicon Village (SE)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1111/bph.70073
- Primary Topic
- Neuroendocrine regulation and behavior
- Type
- article
- Field-Weighted Citation Impact
- 0.00