Dysfunctional mesocorticolimbic circuitry in cluster headache
These findings suggest that chronic CH patients experience an imbalance in the VTA-mPFC pathway, while episodic patients may show early signs of this emerging dysfunction. Moreover, the observed reward processing alterations seem distinct from those associated with affective disorders, possibly highlighting unique mechanisms underlying the pathophysiology of CH.
Authors
- Stefania Ferraro (ORCID: https://orcid.org/0000-0002-5939-0459)
- Massimo Leone (ORCID: https://orcid.org/0000-0001-7475-4049)
- Greta Demichelis (ORCID: https://orcid.org/0000-0003-2034-0283)
- Jean Paul Medina (ORCID: https://orcid.org/0000-0002-6450-0202)
- Anna Nigri (ORCID: https://orcid.org/0000-0002-1197-5458)
- Luca Giani (ORCID: https://orcid.org/0000-0002-9565-5610)
- Marina Grisoli (ORCID: https://orcid.org/0000-0002-7663-446X)
- Benjamin Becker (ORCID: https://orcid.org/0000-0002-9014-9671)
- Susanna Usai (ORCID: https://orcid.org/0000-0002-0606-0691)
- Davide Fedeli (ORCID: https://orcid.org/0000-0001-9732-2353)
- Luisa Chiapparini (ORCID: https://orcid.org/0000-0001-8115-9897)
- Dan Liu (ORCID: https://orcid.org/0000-0002-3283-0004)
- Giuseppe Ciullo (ORCID: https://orcid.org/0009-0007-7355-2606)
- Alberto Cecchini Proietti
- Michael Maes
Institutions
- University of Parma (IT)
- University of Electronic Science and Technology of China (CN)
- Istituti Clinici Scientifici Maugeri (IT)
- Policlinico San Matteo Fondazione (IT)
- Fondazione IRCCS Istituto Neurologico Carlo Besta (IT)
- University of Hong Kong (HK)
Publication Details
- Journal
- The Journal of Headache and Pain
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1186/s10194-025-02017-z
- Citations
- 5
- Primary Topic
- Migraine and Headache Studies
- Type
- article
- Field-Weighted Citation Impact
- 7.36
Funders
- European Commission
- Fondazione Cariplo
- Ministero della Salute
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
- Key Research and Development Program of Sichuan Province