SerpinE2 promotes M2 polarization in macrophage to accelerate colorectal cancer progression
Our study demonstrates that tumor-secreted SERPINE2 mediates a positive feedback loop between tumor cells and M2 macrophages to accelerate cancer progression, suggesting SERPINE2 may be as a promising therapeutic target for colon cancer treatment.
Authors
- Weifeng Yang (ORCID: https://orcid.org/0000-0002-9339-1746)
- Huilong Liu (ORCID: https://orcid.org/0000-0003-3583-7161)
- Wanglin Li (ORCID: https://orcid.org/0000-0002-2103-0271)
- Xu Gao (ORCID: https://orcid.org/0000-0001-9040-4970)
Institutions
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-05-20
- DOI
- https://doi.org/10.3389/fonc.2025.1585935
- Citations
- 1
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Natural Science Foundation of Guangdong Province
- Guilin Medical University
- Basic and Applied Basic Research Foundation of Guangdong Province