Azithromycin treatment response as a probe to attribute bacterial etiologies of diarrhea using molecular diagnostics: a reanalysis of the Antibiotics for Children with Severe Diarrhea (ABCD) trial
The observed associations between azithromycin treatment response and pathogen quantity for <i>Shigella</i>, <i>Vibrio cholerae</i>, ST-ETEC, and tEPEC support prior evidence that these pathogens are likely causes of diarrhea when present in high quantities. Conversely, the absence of a similar response pattern for <i>Campylobacter</i>, LT-ETEC, and EAEC is consistent with large-scale studies showing a limited association between their quantities and diarrhea.
Authors
- Christopher Duggan (ORCID: https://orcid.org/0000-0001-8083-8193)
- Sarah Elwood (ORCID: https://orcid.org/0000-0003-0904-3552)
- Karen L. Kotloff (ORCID: https://orcid.org/0000-0003-1808-6431)
- Elizabeth T. Rogawski McQuade (ORCID: https://orcid.org/0000-0002-4942-3747)
- Patricia B. Pavlinac (ORCID: https://orcid.org/0000-0002-0051-9131)
- Ayesha De Costa (ORCID: https://orcid.org/0000-0003-1869-5990)
- Judd L. Walson (ORCID: https://orcid.org/0000-0003-4836-720X)
- Karim Manji (ORCID: https://orcid.org/0000-0002-7069-6408)
- Queen Dube (ORCID: https://orcid.org/0000-0002-7587-6133)
- James A Platts-Mills (ORCID: https://orcid.org/0000-0002-4956-0418)
- Sunil Sazawal (ORCID: https://orcid.org/0000-0002-8035-9085)
- Samba O. Sow (ORCID: https://orcid.org/0000-0002-6335-5066)
- Jennifer Cornick (ORCID: https://orcid.org/0000-0001-6841-9842)
- Christopher R. Sudfeld (ORCID: https://orcid.org/0000-0002-3203-3638)
- Naor Bar‐Zeev (ORCID: https://orcid.org/0000-0003-0570-4624)
- Benson O. Singa (ORCID: https://orcid.org/0000-0002-6605-324X)
- Farah Naz Qamar
- Tahmeed Ahmed
Institutions
- Aga Khan University (PK)
- University of Maryland, Baltimore (US)
- Boston Children's Hospital (US)
- Johns Hopkins University (US)
- University of Liverpool (GB)
- Emory University (US)
- Muhimbili University of Health and Allied Sciences (TZ)
- University of Washington (US)
- International Centre for Diarrhoeal Disease Research (BD)
- Malawi-Liverpool-Wellcome Trust Clinical Research Programme (MW)
- Johns Hopkins Medicine (US)
- Kenya Medical Research Institute (KE)
- Centre Pour le Développement des Vaccins-Mali (ML)
- World Health Organization (CH)
- The Childhood Acute Illness and Nutrition Network (KE)
- Harvard Global Health Institute (US)
- Queen Elizabeth Central Hospital (MW)
- University of Virginia (US)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-05-20
- DOI
- https://doi.org/10.3389/fmicb.2025.1606207
- Citations
- 1
- Primary Topic
- Viral gastroenteritis research and epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- Bill and Melinda Gates Foundation