Genetic influence of the brain imaging phenotypes, brain and cerebrospinal fluid metabolites and brain genes on migraine subtypes: a Mendelian randomization and multi-omics study
Our study integrates cross-omics analyses to investigate the causal links between brain structure, metabolic alterations, gene expression, and migraine including its MA and MO subtypes. These findings provide novel insights into the pathophysiological mechanisms and potential targets for intervention across migraine subtypes.
Authors
- Meihua Dong
- Jie‐Lin Wang
- Jing Li (ORCID: https://orcid.org/0000-0002-3977-1641)
- Rui Qin (ORCID: https://orcid.org/0000-0003-4093-7044)
- Ping-An Zhang (ORCID: https://orcid.org/0000-0003-4914-9167)
- Na Li (ORCID: https://orcid.org/0000-0003-0193-1475)
- Xiang-Chun Huang
Institutions
- First Affiliated Hospital of Guangzhou Medical University (CN)
- State Key Laboratory of Respiratory Disease (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- The Journal of Headache and Pain
- Published
- 2025-05-20
- DOI
- https://doi.org/10.1186/s10194-025-02063-7
- Citations
- 5
- Primary Topic
- Migraine and Headache Studies
- Type
- article
- Field-Weighted Citation Impact
- 7.36
Funders
- National Natural Science Foundation of China
- Guangzhou Municipal Science and Technology Project