Higher circulating FGF21, lower protein intake, and lower muscle mass: Associations with a higher risk of mortality
Higher FGF21 was associated with higher odds of low protein intake. The observed association of higher FGF21 concentrations and risk mortality was predominantly attributable to lower protein intake. In contrast, both higher protein intake and higher muscle mass were independently associated with lower mortality risk, highlighting the potential relevance of protein intake and maintenance of muscle mass in long-term health.
Authors
- Wendy Dam
- Adrian Post (ORCID: https://orcid.org/0000-0001-8645-1627)
- Dion Groothof (ORCID: https://orcid.org/0000-0002-1886-4451)
- Stephan J. L. Bakker (ORCID: https://orcid.org/0000-0003-3356-6791)
- Robin P. F. Dullaart (ORCID: https://orcid.org/0000-0002-3844-5254)
- Casper F. M. Franssen (ORCID: https://orcid.org/0000-0003-1004-9994)
Institutions
- University Medical Center Groningen (NL)
- University of Groningen (NL)
Publication Details
- Journal
- Journal of Internal Medicine
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1111/joim.20099
- Citations
- 2
- Primary Topic
- Fibroblast Growth Factor Research
- Type
- article
- Field-Weighted Citation Impact
- 1.61