Restoring Prostacyclin/PGI2-PTGIR signaling alleviates intestinal fibrosis in Crohn’s disease via fibroblast-specific YAP/TAZ inhibition
The antifibrotic effects of PGI2-PTGIR signaling are impaired in CD. Restoring PGI2-PTGIR signaling is a pharmacologically tractable and cell-selective approach to targeting YAP/TAZ via PTGIR, which reverses intestinal fibrosis.
Authors
- Peng Du (ORCID: https://orcid.org/0000-0001-9355-0789)
- W. Yaosheng (ORCID: https://orcid.org/0000-0001-5109-1473)
- Chen‐Ying Liu (ORCID: https://orcid.org/0000-0002-8930-6182)
- Zhebin Hua (ORCID: https://orcid.org/0000-0002-9227-3625)
- Yingwei Chen (ORCID: https://orcid.org/0000-0001-8429-252X)
- Weijun Ou
- Wensong Ge
- Xiaolei Wang (ORCID: https://orcid.org/0000-0003-2023-6670)
- Weimin Xu (ORCID: https://orcid.org/0000-0002-6607-5086)
- Wenjun Ding (ORCID: https://orcid.org/0000-0002-0233-0033)
Institutions
- Tongji University (CN)
- XinHua Hospital (CN)
- Shanghai Cancer Institute (CN)
- Cancer Research Center (US)
- Shanghai Tenth People's Hospital (CN)
Publication Details
- Journal
- Journal of Crohn s and Colitis
- Published
- 2025-05-20
- DOI
- https://doi.org/10.1093/ecco-jcc/jjaf084
- Citations
- 4
- Primary Topic
- Cytokine Signaling Pathways and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 4.18
Funders
- Natural Science Foundation of Shanghai
- National Natural Science Foundation of China