The angiotensin receptor blocker, losartan, reduces inflammation and fibrosis, and prevents relapse of fibrosis after steroid-induced remission, in mice prone to Crohn’s disease-like ileitis
Losartan, and other drugs targeting the RAS, may serve as an effective treatment to successfully dampen intestinal fibrosis during active inflammation, as well as prevent its progression after corticosteroid-induced remission in Crohn's patients.
Authors
- Giovanni Latella (ORCID: https://orcid.org/0000-0001-6341-5711)
- H. S. Friedman
- Paúl Cordero (ORCID: https://orcid.org/0000-0001-9236-2268)
- Jude A. Oben (ORCID: https://orcid.org/0000-0003-3350-8356)
- Jeremy Sanderson (ORCID: https://orcid.org/0000-0002-0556-6965)
- Carlo De Salvo (ORCID: https://orcid.org/0000-0002-1523-1915)
- K. Gonca Akbulut (ORCID: https://orcid.org/0000-0001-6256-3616)
- A. M. Gómez-Uriz
- Serena Artone (ORCID: https://orcid.org/0009-0007-3108-5755)
- Davide Pietropaoli (ORCID: https://orcid.org/0000-0001-9585-1809)
- Theresa T. Pizarro (ORCID: https://orcid.org/0000-0003-3163-915X)
- Stefania De Santis (ORCID: https://orcid.org/0000-0001-6877-2208)
- Joseph Jay Williams (ORCID: https://orcid.org/0000-0002-9122-5242)
- I. C. Hart
- Tommaso Lorenzo Parigi (ORCID: https://orcid.org/0000-0002-3398-0231)
- Shuvra Ray
- Elakia Vadivelan
- Anna V Saline
Institutions
- University of North Carolina at Chapel Hill (US)
- St Thomas' Hospital (GB)
- Guy's and St Thomas' NHS Foundation Trust (GB)
- University of L'Aquila (IT)
- San Salvatore Hospital (IT)
- St. Thomas Hospital (CA)
- IRCCS Ospedale San Raffaele (IT)
- University School (US)
- University College London (GB)
- Case Western Reserve University (US)
Publication Details
- Journal
- Journal of Crohn s and Colitis
- Published
- 2025-05-20
- DOI
- https://doi.org/10.1093/ecco-jcc/jjaf083
- Citations
- 5
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 9.09