STUDY ON THE THERAPEUTIC EFFICACY OF AN ORAL IVERMECTIN AND PRAZIQUANTEL PREPARATION AGAINST SOME PARASITIC DISEASES OF CATTLE

A study on the therapeutic efficacy of an ivermectin and praziquantel combination against parasitic diseases in cattle established that this combination exhibits high activity against both endoparasites and ectoparasites. When administered orally with feed at a dose of 1 mL/20 kg of body weight, the drug provided 90–92% extense-effectiveness and 95–100% intense-effectiveness. It demonstrated excellent results against monieziasis, dictyocaulosis, strongyloidiasis, and arachnoentomosis, including ixodidosis, sarcoptic mange, chorioptosis, boviculosis, and siphunculatosis. Clinical examinations and laboratory tests (coproovoscopy, larvoscopy) confirmed therapy success. Ivermectin and praziquantel caused no side effects or toxic reactions, which confirms their safety and high tolerability in animals. The testing was conducted on animals naturally infected with parasites in the Kaliningrad Region, which allowed us to assess drug efficacy in a real epizootic situation. The results confirm that this combination not only effectively eliminates parasitic infections but also improves overall health of cattle with increasing productivity, strengthening immunity, and reducing the risk of reinfection.