Asymmetric Formal Synthesis of (−)-Paroxetine
A concise, asymmetric formal synthesis of (-)-paroxetine is reported. The synthetic strategy features an asymmetric hydrogenation for constructing the chiral center and a phosphate-group-involved intramolecular S<sub>N</sub>2 reaction for the construction of the <i>trans</i>-3,4-disubstituted piperidine scaffold. This synthetic route is concise and practical for (-)-paroxetine synthesis.
Authors
- Sunliang Cui (ORCID: https://orcid.org/0000-0001-9407-5190)
- Lei Liu (ORCID: https://orcid.org/0000-0002-0839-373X)
- Xianjing Zhou
- Wen-Feng Huang (ORCID: https://orcid.org/0009-0000-5193-6747)
Institutions
- Jinhua Academy of Agricultural Sciences (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1021/acs.orglett.5c01622
- Citations
- 1
- Primary Topic
- Asymmetric Synthesis and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China
- National Program for Support of Top-notch Young Professionals
- Natural Science Foundation of Zhejiang Province