THE EFFICACY OF THE COMBINATION DRUG AGAINST APHANIPTEROSIS IN CATS

The insecticidal efficacy and safety of a new combination drug in tablet formulation based on derivatives of spinosyns, pyrimidines and pyrazinoisoquinoline against aphanipterosis in cats was studied. The study was carried out on 16 animals with spontaneous infestation with fleas Ctenocephalides spp. which were divided into two groups: experimental and control groups of 8 animals each. The animals of the experimental group were given the drug individually, once, orally, on the root of the tongue immediately after feeding in the minimum dose per 1 kg of animal weight (by active ingredients): 50 mg of spinosyn derivative, 15 mg of pyrimidine derivative and 5 mg of pyrazinoisoquinoline derivative. The animals of the control group did not receive the drug. The animals were examined, and insects were counted before the drug and at 2, 7, 14, 28 and 38 days after application with determination of the prevalence (P), the infection intensity (II), and the treatment extense-effectiveness (EE). After using the drug, there was a significant decrease in the insects in the first 48 hours after the drug. The insecticidal action was 28–32 days. The administration of the medicinal product has no adverse effect or side effects in cats in the recommended regimen and dose.