<scp>TCF3</scp> :: <scp>ZNF384</scp> induces steroid resistance in B‐cell precursor acute lymphoblastic leukemia cells
Our data suggest that the acquisition of dexamethasone resistance in BCP-ALL cell lines is an effect of TCF3::ZNF384 protein distinct from EP300::ZNF384. Other than the common functions of ZNF384-r that contribute to the development of leukemia with a lineage-ambiguous phenotype, TCF3::ZNF384 may exhibit a fusion partner-dependent function distinct from EP300::ZNF384 and participate in the formation of characteristic clinical features of TCF3::ZNF384-expressing ALL patients.
Authors
- Toshiaki Shimizu (ORCID: https://orcid.org/0000-0003-0364-0022)
- Masao Hori
- Shinpei Kusano (ORCID: https://orcid.org/0000-0002-9949-1529)
- Kentaro Ohki (ORCID: https://orcid.org/0000-0003-2838-4555)
- Nobutaka Kiyokawa (ORCID: https://orcid.org/0000-0001-9310-2126)
- Hitomi Ueno‐Yokohata (ORCID: https://orcid.org/0000-0002-0296-5303)
- Takeshi Ishibashi
- Junya Fujimura (ORCID: https://orcid.org/0000-0002-8542-013X)
Institutions
- Yokohama National University (JP)
- Juntendo University (JP)
- National Center For Child Health and Development (JP)
Publication Details
- Journal
- Pediatrics International
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1111/ped.70078
- Citations
- 1
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 1.88
Funders
- National Center for Child Health and Development
- Japan Agency for Medical Research and Development