Antidiabetic Potential of Combined Cassiavera and Morel Berry Ethanol Extracts in Diabetic Rats

This study investigated the effects of a combination of cassiavera and morel berry ethanol extracts (CMBEs) on diabetic rats, focusing on blood glucose levels, lipid profiles, immune and inflammatory markers, and pancreatic histopathology. Twenty male albino Wistar rats were divided into four groups: Group A (normal rats), Group B (diabetic rats), Group C (diabetic rats treated with metformin), and Group D (diabetic rats treated with CMBE). Parameters such as the IC₅₀ of CMBE, body weight, blood glucose levels, lipid profile, immune markers (leukocyte percentage, total count, and macrophage activity), inflammatory markers (TNF-<i>α</i> and IL-6), and pancreatic histopathology of rats were assessed for 7 weeks. Statistical analysis was performed using one-way analysis of variance followed by Duncan's multiple range test, with a significance level of <i>α</i> = 5%. The results revealed an IC₅₀ value of 18.5338 ppm for CMBE. Weight gain was observed in all groups except Group B, in which rats lost weight. CMBE was notably effective in lowering blood glucose levels in diabetic rats, with rats in Group D exhibiting higher HDL cholesterol levels and total leukocyte counts compared with those in Group C. Furthermore, CMBE significantly reduced TNF-<i>α</i> and IL-6 levels, exhibiting promising potential in promoting pancreatic repair. This study highlights the potential of a combination of Cassiavera and Morel Berry extract as an effective antidiabetic agent, suggesting it as a valuable addition to functional food formulations.