A Role for High Mobility Group Box 1 (<scp>HMGB1</scp>) Release in the Pathogenesis of Gastroesophageal Reflux Disease
Release of HMGB1 from esophageal epithelial cells by weakly acidic bile salts, inhibited by curcumin, and increased expression of TLR4 and RAGE in ERD mucosa suggest this pathway has a role in GORD. Modulating HMGB1 activity may be a strategy for treating recurrent symptoms.
Authors
- Madusha Peiris (ORCID: https://orcid.org/0000-0003-4429-5931)
- Philip Woodland (ORCID: https://orcid.org/0000-0003-2445-9724)
- Diana C. Blaydon (ORCID: https://orcid.org/0000-0002-9998-2563)
- Tom Leech (ORCID: https://orcid.org/0000-0002-7053-2593)
- David P. Kelsell (ORCID: https://orcid.org/0000-0002-9910-7144)
Institutions
- Queen Mary University of London (GB)
Publication Details
- Journal
- Neurogastroenterology & Motility
- Published
- 2025-05-20
- DOI
- https://doi.org/10.1111/nmo.70083
- Citations
- 1
- Primary Topic
- Gastroesophageal reflux and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.81
Funders
- Reckitt Benckiser Pharmaceuticals