Combinational Radiotherapies Improve Brain Cancer Treatment at High Dose Rates In Vitro
Our results demonstrate that highly synergistic combination treatments using UHDR synchrotron radiation can yield significantly improved brain cancer killing compared with conventional radiotherapy. We anticipate that these additive, multi-modal combination therapies will provide options for more targeted and effective use of radiotherapies for the future treatment of brain cancer.
Authors
- Stéphanie Corde (ORCID: https://orcid.org/0000-0003-0388-7340)
- E. Engels (ORCID: https://orcid.org/0000-0003-4704-2104)
- Alice O’Keefe
- Sarah Vogel
- Abass Khochaiche
- Michael Valceski (ORCID: https://orcid.org/0000-0002-1967-1774)
- Moeava Tehei (ORCID: https://orcid.org/0000-0003-3654-6833)
- Jason Paino (ORCID: https://orcid.org/0000-0002-3648-7880)
- Anatoly Rosenfeld (ORCID: https://orcid.org/0000-0001-5116-6308)
- Carolyn Hollis (ORCID: https://orcid.org/0000-0003-3225-1042)
- Michael Lerch (ORCID: https://orcid.org/0000-0002-2406-9972)
- Matthew Cameron (ORCID: https://orcid.org/0000-0002-0937-6309)
- Micah Barnes
- Dave Potter
- Kiarn Roughley (ORCID: https://orcid.org/0009-0001-7190-0773)
Institutions
- Australian Nuclear Science and Technology Organisation (AU)
- University of Wollongong (AU)
- Australian Synchrotron (AU)
- Prince of Wales Hospital (AU)
Publication Details
- Journal
- Cancers
- Published
- 2025-05-20
- DOI
- https://doi.org/10.3390/cancers17101713
- Primary Topic
- Advanced Electron Microscopy Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Australian Synchrotron