All-Trans Retinoic Acid Induces Differentiation and Downregulates Stemness Markers and MGMT Expression in Glioblastoma Stem Cells
Five-day exposure to ATRA diminishes SOX2, Nestin, and MGMT at both mRNA and protein levels in stem-enriched GBM cultures, supporting the premise that ATRA-induced differentiation can concurrently blunt CSC traits and TMZ-resistance mechanisms. These data provide a molecular rationale for testing ATRA in combination regimens aimed at improving GBM therapy.
Authors
- Justin Tang (ORCID: https://orcid.org/0000-0001-6658-2558)
- Raymond S. H. Yang
Institutions
- Health Canada (CA)
- University of Guelph (CA)
Publication Details
- Journal
- Cells
- Published
- 2025-05-20
- DOI
- https://doi.org/10.3390/cells14100746
- Citations
- 1
- Primary Topic
- Retinoids in leukemia and cellular processes
- Type
- article
- Field-Weighted Citation Impact
- 0.81