Performance of a Novel Stool Quantitative Polymerase Chain Reaction Assay for Pediatric Tuberculosis Detection in Sub-Saharan Africa
This stool qPCR assay can increase the microbiologic confirmation of tuberculosis in pediatric populations from TB high-burden settings. It may be particularly useful where resource limitations or clinical capacity impedes diagnostic specimen collection via sputum induction or gastric aspiration.
Authors
- Lilian Komba
- H. Lester Kirchner (ORCID: https://orcid.org/0000-0002-2557-6749)
- Edson Mambuque (ORCID: https://orcid.org/0000-0002-9106-1444)
- Alexander Kay (ORCID: https://orcid.org/0000-0001-5283-4697)
- Shilzia Munguambe (ORCID: https://orcid.org/0000-0002-5433-727X)
- Anna M. Mandalakas (ORCID: https://orcid.org/0000-0002-8091-3509)
- Clement Gascua Adu-Gyamfi (ORCID: https://orcid.org/0000-0002-3190-9343)
- Tara Ness (ORCID: https://orcid.org/0000-0002-4425-418X)
- Christoph Lange (ORCID: https://orcid.org/0000-0002-9691-4741)
- Lucía Carratalá-Castro (ORCID: https://orcid.org/0000-0003-2355-6477)
- Bariki Mtafya (ORCID: https://orcid.org/0000-0003-3772-8671)
- Alberto L. García‐Basteiro (ORCID: https://orcid.org/0000-0002-2038-5505)
- Sozinho Acácio (ORCID: https://orcid.org/0000-0002-3173-6446)
- Joanna Ehrlich (ORCID: https://orcid.org/0000-0001-7828-7222)
- Andrew R. DiNardo (ORCID: https://orcid.org/0000-0001-5990-6470)
- Durbbin Mulengwa (ORCID: https://orcid.org/0000-0003-0536-7859)
- Anca Vasiliù (ORCID: https://orcid.org/0000-0001-5336-7859)
- Miguel Cumbe
- Babongile Nkala (ORCID: https://orcid.org/0009-0004-9857-2038)
- Nosisa Shiba
- Abigail Seeger
Institutions
- National Health Laboratory Service (ZA)
- Geisinger Medical Center (US)
- Radboud University Nijmegen (NL)
- Baylor College of Medicine (US)
- University of the Witwatersrand (ZA)
- Radboud University Medical Center (NL)
- Mbeya University of Science and Technology (TZ)
- Baylor College of Medicine Children’s Foundation (UG)
- Radboud Institute for Molecular Life Sciences (NL)
- German Center for Infection Research (DE)
- Manhiça Health Research Centre (MZ)
- Research Center Borstel - Leibniz Lung Center (DE)
- Children’s Foundation (GB)
- Barcelona Institute for Global Health (ES)
- Monterey Bay Aquarium Foundation (US)
- National Institute for Medical Research (TZ)
- Geisinger Health System (US)
- Universitat de Barcelona (ES)
- University of Lübeck (DE)
Publication Details
- Journal
- Journal of the Pediatric Infectious Diseases Society
- Published
- 2025-05-20
- DOI
- https://doi.org/10.1093/jpids/piaf045
- Citations
- 2
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 2.79