Repurposing antimalarials: pyrimethamine exhibits superior <i>in vitro</i> activity to metronidazole against <i>Gardnerella</i> while sparing <i>Lactobacillus</i>
These findings suggest that pyrimethamine (and sulfadoxine/pyrimethamine) could be promising alternative or adjuvant therapies for BV, warranting further clinical trials.
Authors
- Harry P. de Koning (ORCID: https://orcid.org/0000-0002-9963-1827)
- Aliona S. Rosca (ORCID: https://orcid.org/0000-0001-6880-4732)
- Piet Cools (ORCID: https://orcid.org/0000-0003-2980-5307)
- Enesia Banda Chaponda
- R Matthew Chico (ORCID: https://orcid.org/0000-0003-1795-7100)
- Thomas Beckers (ORCID: https://orcid.org/0000-0003-1718-0338)
Institutions
- Ghent University (BE)
- University of Zambia (ZM)
- London School of Hygiene & Tropical Medicine (GB)
- University of Glasgow (GB)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2025-05-20
- DOI
- https://doi.org/10.1093/jac/dkaf157
- Citations
- 2
- Primary Topic
- Reproductive tract infections research
- Type
- article
- Field-Weighted Citation Impact
- 2.37
Funders
- Wellcome Trust
- Department of Health and Social Care
- Medical Research Council Canada
- Foreign, Commonwealth and Development Office
- Medical Research Council