Real-world use of a hydrophilic curcumin-based oral formulation in the management of macular oedema: a collection of clinical experiences

This is a collection of clinical experiences exploring the real-world effectiveness of a hydrophilic curcumin-based oral formulation (CHC, Diabec<sup>®</sup>) in the management of macular oedema across diverse retinal conditions, including diabetic macular oedema, central serous chorioretinopathy, branch retinal vein occlusion and Irvine-Gass syndrome. Eight cases reported significant improvements in best-corrected visual acuity and central macular thickness, with complete resolution of oedema in some instances. CHC was well tolerated, with no adverse effects reported. These findings suggest that CHC is a safe and effective adjunct or standalone therapy for chronic or refractory macular oedema, enhancing anatomical and functional outcomes in real-world settings.

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Publication Details

Journal
Drugs in Context
Published
2025-05-20
DOI
https://doi.org/10.7573/dic.2025-3-3
Primary Topic
Retinoids in leukemia and cellular processes
Type
article
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article

Real-world use of a hydrophilic curcumin-based oral formulation in the management of macular oedema: a collection of clinical experiences

Giuseppe Covello, Davide Allegrini, Maura Mancini, Anna Vecchiarelli et al.
Drugs in Context
Retinoids in leukemia and cellular processes
article

Real-world use of a hydrophilic curcumin-based oral formulation in the management of macular oedema: a collection of clinical experiences

Giuseppe Covello, Davide Allegrini, Maura Mancini, Anna Vecchiarelli, Mary Romano, Arianna Mancini, Alessandra Mancini, Mario Rosario Romano
article en

Abstract

This is a collection of clinical experiences exploring the real-world effectiveness of a hydrophilic curcumin-based oral formulation (CHC, Diabec<sup>®</sup>) in the management of macular oedema across diverse retinal conditions, including diabetic macular oedema, central serous chorioretinopathy, branch retinal vein occlusion and Irvine-Gass syndrome. Eight cases reported significant improvements in best-corrected visual acuity and central macular thickness, with complete resolution of oedema in some instances. CHC was well tolerated, with no adverse effects reported. These findings suggest that CHC is a safe and effective adjunct or standalone therapy for chronic or refractory macular oedema, enhancing anatomical and functional outcomes in real-world settings.

Drugs in ContextVol. 14
University of Pisa (IT), University of Messina (IT), Humanitas University (IT), Magna Graecia University (IT), IRCCS Humanitas Research Hospital (IT)
Zero hunger
Openalex Percentile: Top 90%
Retinoids in leukemia and cellular processes
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Real-world use of a hydrophilic curcumin-based oral formulation in the management of macular oedema: a collection of clinical experiences — Giuseppe Covello, Davide Allegrini, et al. · Drugs in Context (2025) | TGRS Research Map | TGRS