Real-world use of a hydrophilic curcumin-based oral formulation in the management of macular oedema: a collection of clinical experiences
This is a collection of clinical experiences exploring the real-world effectiveness of a hydrophilic curcumin-based oral formulation (CHC, Diabec<sup>®</sup>) in the management of macular oedema across diverse retinal conditions, including diabetic macular oedema, central serous chorioretinopathy, branch retinal vein occlusion and Irvine-Gass syndrome. Eight cases reported significant improvements in best-corrected visual acuity and central macular thickness, with complete resolution of oedema in some instances. CHC was well tolerated, with no adverse effects reported. These findings suggest that CHC is a safe and effective adjunct or standalone therapy for chronic or refractory macular oedema, enhancing anatomical and functional outcomes in real-world settings.
Authors
- Giuseppe Covello (ORCID: https://orcid.org/0000-0002-8523-2032)
- Davide Allegrini (ORCID: https://orcid.org/0000-0002-5988-706X)
- Maura Mancini (ORCID: https://orcid.org/0009-0009-2615-436X)
- Anna Vecchiarelli (ORCID: https://orcid.org/0000-0002-3185-6720)
- Mary Romano (ORCID: https://orcid.org/0000-0002-1344-8467)
- Arianna Mancini (ORCID: https://orcid.org/0000-0001-8888-0409)
- Alessandra Mancini (ORCID: https://orcid.org/0000-0001-7719-5772)
- Mario Rosario Romano (ORCID: https://orcid.org/0000-0003-0348-0532)
Institutions
- University of Pisa (IT)
- University of Messina (IT)
- Humanitas University (IT)
- Magna Graecia University (IT)
- IRCCS Humanitas Research Hospital (IT)
Publication Details
- Journal
- Drugs in Context
- Published
- 2025-05-20
- DOI
- https://doi.org/10.7573/dic.2025-3-3
- Primary Topic
- Retinoids in leukemia and cellular processes
- Type
- article
- Field-Weighted Citation Impact
- 0.00