DYSMETABOLIC CHANGES IN GOATS WITH MASTITIS IN THE PRESENCE OF OBSTRUCTIVE PATHOLOGIES IN THE URINARY SYSTEM

In a comprehensive diagnosis 47 dairy goats in the postpartum period were involved; according to data analysis, among all examined dairy goats, the kidney pathology was found in 26.8% of animals with subclinical mastitis, and in goats with clinical mastitis this indicator is 34.5%. Goats are most susceptible to inflammatory processes in the mammary gland at the beginning of lactation, while there is a significant increase in the urea content – up to 9.32 mmol/L, and creatinine to 123.45 mmol/L. In goats with clinical mastitis, the urea content is 6.78 mmol/L, and creatinine is 95.72 mmol/L. Such changes may indicate azotemia, and sometimes uremia. A significant decrease in the number of T-helpers and T-suppressors was found, the decrease in the number of T-helpers was 32.8% (p<0.001), and T-suppressors was 30.9% (p<0.001) in goats with the udder disease during the postpartum period. It was found that the level of ceruloplasmin ranged on average 74.28±7.97 mg/dl in the blood of goats with clinical mastitis, while subclinical mastitis ranged 47.94±6.74 mg/dl, and in the control group (clinically healthy), the level of ceruloplasmin ranged from 27.73±2.32 mg/dl. Leukocyte cylinders are secreted in the urine of 12.6% of goat patients with subclinical mastitis. Granular cylinders were diagnosed in 9.2% of goats with clinical mastitis. Hyaline cylinders were found in 6.9% of goat with clinical mastitis and 6.0% of goat with subclinical mastitis. The results of a general urinalysis showed the presence of proteinuria over 0.3 g/l. Analysis of statistical data showed that in lactating goats with mastitis combined with renal hydronephrosis, the renal failure was observed in 10.7% of cases with clinical mastitis and in 4.7% of cases with subclinical mastitis.